Combination therapy of 3-methylcholanthrene-induced mammary carcinoma in rats: effect of chemotherapy, ovariectomy, and food restriction.
نویسندگان
چکیده
The growth of mammary carcinoma induced by oral 3-methylcholanthrene in female Wistar rats is retarded by ovariectomy and by food restriction sufficient to produce 12-14% body weight loss. Estradici benzoate (NSC 9566), 5-fluorouracil (NSC 19893), miracil D (NSC 14574), mitomycin C (NSC 26980), and AB-100 (NSC 37095) showed inhibitory activity. The best tumor inhibition without mortality was elicited by ovariectomy com bined with food restriction, and by ovariectomy combined with estradici benzoate.
منابع مشابه
Combination Therapy of 3-Methylcholanthrene-induced Mammary Carcinoma in Rats: Effect of Chemotherapy, Ovariectomy, and Food Restriction1
The growth of mammary carcinoma induced by oral 3-methylcholanthrene in female Wistar rats is retarded by ovariectomy and by food restriction sufficient to produce 12-14% body weight loss. Estradici benzoate (NSC 9566), 5-fluorouracil (NSC 19893), miracil D (NSC 14574), mitomycin C (NSC 26980), and AB-100 (NSC 37095) showed inhibitory activity. The best tumor inhibition without mortality was el...
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ورودعنوان ژورنال:
- Cancer research
دوره 27 1 شماره
صفحات -
تاریخ انتشار 1967